Abciximab
Severe
Database
Clinical effect not specified
Source: DDInter
Drug reference
lepirudin
Recombinant hirudin · Anticoagulant
Recombinant hirudinAnticoagulant
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
- AbciximabSevereDatabaseDDInter
- AcalabrutinibSevereDatabaseDDInter
- AlteplaseSevereDatabaseDDInter
- AnagrelideSevereDatabaseDDInter
Mechanism
Recombinant form of hirudin.
Indications
Treating thrombosis in the setting of heparin-induced thrombocytopeniaPatients at risk of heparin induced thrombocytopenia
Dosing
- Renal adjustment
- Should be used cautiously in patients with decreased renal function, and serum creatinine should be monitored daily.
Pharmacokinetics
Half-life
Approximately 2 hours after subcutaneous administration, approximately 10 minutes after intravenous infusion
Excretion
Eliminated by the kidneys
Side effects
Serious
- Anaphylaxis (possibility on repeated/prolonged administration if antibodies against lepirudin-thrombin complex develop)
Drug interactions
Acalabrutinib
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Alteplase
Severe
Database
Clinical effect not specified
Source: DDInter
Anagrelide
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Anisindione
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Anistreplase
Severe
Database
Clinical effect not specified
Source: DDInter
Apixaban
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Ardeparin
Severe
Database
Clinical effect not specified
Source: DDInter
Avapritinib
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Betrixaban
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Bivalirudin
Severe
Database
Clinical effect not specified
Source: DDInter
Cabozantinib
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Related guidelines
GI bleeding on antiplatelet or anticoagulant therapy
CSI · Cardiology · 2020
Anticoagulant management for dental procedures
ADA_DENTAL · Dentistry · 2015
Venous thromboembolism prophylaxis
ASH · Haematology · 2018
Hepatitis B — chronic infection
WHO · Hepatology · 2025
Cervical cancer screening and management
ICMR · Oncology · 2022
Ask House about lepirudin
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e, Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team