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Drug reference

lofexidine

Alpha-2 adrenergic receptor agonist · Opioid withdrawal treatment

Alpha-2 adrenergic receptor agonistOpioid withdrawal treatment
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
  • AmiodaroneSevereDatabaseDDInter
  • AmisulprideSevereDatabaseDDInter
  • AnagrelideSevereDatabaseDDInter
  • Arsenic TrioxideSevereDatabaseDDInter

Mechanism

Lofexidine is an alpha-2 adrenergic receptor agonist.

Indications

Opioid withdrawalHypertension

Dosing

Adult
3.2 mg/day split into four doses (for opioid withdrawal)

Side effects

Common
Postural hypotension

Drug interactions

Amiodarone
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Amisulpride
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Anagrelide
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Arsenic Trioxide
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Bedaquiline
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Bepridil
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Cabozantinib
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Ceritinib
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Chloroquine
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Cisapride
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Citalopram
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Clozapine
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Related guidelines

Beta-blockers in hypertension
MOHFW · Cardiology · 2024
Hypertension in diabetes
MOHFW · Endocrinology · 2024
Hypertension in adults
OTHER · Cardiology · 2022
Hypertension in diabetes
RSSDI · Endocrinology · 2022
Hypertension in adults
MOHFW · Cardiology · 2021

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Textbook-sourced·Sources: Goodman & Gilman 14e·Updated: 2026-05-10