Dihydroergotamine
Severe
Database
Clinical effect not specified
Source: DDInter
Drug reference
mephentermine
Mixed action sympathomimetic · Pressor agent, Cardiac stimulant
Mixed action sympathomimeticPressor agent, Cardiac stimulant
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
11 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 11 →
- DihydroergotamineSevereDatabaseDDInter
- Ergotamine TartrateSevereDatabaseDDInter
- IsocarboxazidSevereDatabaseDDInter
- LinezolidSevereDatabaseDDInter
Mechanism
Mephentermine produces both cardiac stimulation and vasoconstriction by directly activating α and β adrenergic receptors as well as by releasing noradrenaline (NA). It increases cardiac output, systolic and diastolic BP.
Indications
Prevent and treat hypotension due to spinal anaesthesia and surgical proceduresShock in myocardial infarctionOther hypotensive states
Dosing
- Adult
- 10–20 mg oral/i.m., also by slow i.v. infusion
Pharmacokinetics
Duration
2–6 hr
Side effects
Common
Excitatory effects (at higher doses)
Drug interactions
Ergotamine Tartrate
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Isocarboxazid
Severe
Database
Clinical effect not specified
Source: DDInter
Linezolid
Severe
Database
Clinical effect not specified
Source: DDInter
Methylene Blue
Severe
Database
Clinical effect not specified
Source: DDInter
Methylergometrine
Severe
Database
Clinical effect not specified
Source: DDInter
Methysergide
Severe
Database
Clinical effect not specified
Source: DDInter
Phenelzine
Severe
Database
Clinical effect not specified
Source: DDInter
Procarbazine
Severe
Database
Clinical effect not specified
Source: DDInter
Selegiline
Severe
Database
Clinical effect not specified
Source: DDInter
Tranylcypromine
Severe
Database
Clinical effect not specified
Source: DDInter
1 additional low-confidence interaction hidden — those rows lack a documented mechanism or management plan in our sources.
Related guidelines
ST-elevation myocardial infarction
CSI · Cardiology · 2020
Preoperative cardiac evaluation for non-cardiac surgery
AHA · Cardiology · 2025
Infective endocarditis prevention
NICE · Cardiology / Dentistry · 2008
Infective endocarditis prevention
AHA · Cardiology / Dentistry · 2007
Acute coronary syndrome
CSI · Cardiology · 2022
Ask House about mephentermine
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e·Verified: 2026-05-10 · House clinical team