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mestranol

Semisynthetic Estrogen · Contraceptive

Semisynthetic EstrogenContraceptive
CDSCO approved
EXCRETION
not curated
INTERACTIONS
11 major
SEVERE in our sources
PREGNANCY
X
FDA category + note
Top interactionssee all 11
  • BexaroteneSevereDatabaseDDInter
  • BosentanSevereDatabaseDDInter
  • CarfilzomibSevereDatabaseDDInter
  • DantroleneSevereDatabaseDDInter

Mechanism

Not yet extracted

Indications

hormonal contraception

Dosing

Adult
0.1–0.2 mg/day oral

Pharmacokinetics

Metabolism
rapid hepatic demethylation to ethinyl estradiol (active form)

Pregnancy & lactation

Pregnancy

X

Drug interactions

Bexarotene
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Bosentan
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Carfilzomib
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Dantrolene
Severe
Database

Clinical effect not specified

Source: DDInter

Felbamate
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Fosphenytoin
Severe
Database

Clinical effect not specified

Source: DDInter

Hemin
Severe
Database

Clinical effect not specified

Source: DDInter

Lenalidomide
Severe
Database

Clinical effect not specified

Source: DDInter

Mycophenolic Acid
Severe
Database

Clinical effect not specified

Source: DDInter

Pomalidomide
Severe
Database

Clinical effect not specified

Source: DDInter

Thalidomide
Severe
Database

Clinical effect not specified

Source: DDInter

1 additional low-confidence interaction hidden — those rows lack a documented mechanism or management plan in our sources.

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Sources: KD Tripathi 7e, Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team