methanol

Methanol is metabolized by alcohol and aldehyde dehydrogenases to formaldehyde and formic acid. The rate of metabolism is slower than ethanol. The toxic effects are largely due to formic acid, which accumulates in the body due to its slow further metabolism and folate dependence.

Adult

Blood level of >50 mg/dl methanol is associated with severe poisoning. Even 15 ml of methanol has caused blindness and 30 ml has caused death; fatal dose is regarded to be 75–100 ml.