Alfentanil
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Drug reference
Methocarbamol
Muscle Relaxant · Antispasmodic
Also known as Robaxin, Robinax
Muscle RelaxantAntispasmodic
CDSCO approvedSchedule H
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
- AlfentanilSevereDatabaseDDInter
- BenzhydrocodoneSevereDatabaseDDInter
- BuprenorphineSevereDatabaseDDInter
- ButorphanolSevereDatabaseDDInter
Mechanism
Methocarbamol is a centrally acting muscle relaxant. It is suggested that these drugs act primarily at the level of the brainstem and spinal cord by selectively inhibiting polysynaptic reflexes. Its action may also involve sedative properties and blockade of nociceptive pathways, decreasing muscle tone without significantly reducing voluntary power.
Indications
Acute muscle spasm caused by local tissue trauma or muscle strainsReflex muscle spasmsChronic neurological diseasesOrthopedic proceduresTetanusMuscle relaxationreflex muscle spasms (orally)chronic neurological diseases (orally)orthopedic procedures (i.v.)tetanus (i.v.)
Dosing
- Adult
- Oral: 0.5 g three times daily. Parenteral: 100 mg/ml solution for IV or IM use.
Pharmacokinetics
Duration
longer acting than mephenesin
Side effects
Common
SedationGastric irritation
Drug interactions
Benzhydrocodone
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Buprenorphine
Severe
Database
Drug interaction classified as: synergy.
Source: DDInter
Butorphanol
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Codeine
Severe
Database
Drug interaction classified as: synergy.
Source: DDInter
Dextropropoxyphene
Severe
Database
Clinical effect not specified
Source: DDInter
Dezocine
Severe
Database
Clinical effect not specified
Source: DDInter
Dihydrocodeine
Severe
Database
Clinical effect not specified
Source: DDInter
Fentanyl
Severe
Database
Drug interaction classified as: synergy.
Source: DDInter
Hydrocodone
Severe
Database
.
Source: DDInter
Hydromorphone
Severe
Database
.
Source: DDInter
Levacetylmethadol
Severe
Database
Clinical effect not specified
Source: DDInter
Related guidelines
Skin and soft tissue infections
IDSA · Infectious Diseases · 2010
Glomerular diseases
KDIGO · Nephrology · 2021
Anticoagulant management for dental procedures
ADA_DENTAL · Dentistry · 2015
Trauma in elderly and frail patients
WSES · Surgery · 2023
Infective endocarditis prevention
NICE · Cardiology / Dentistry · 2008
Other Muscle Relaxant drugs
Ask House about Methocarbamol
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e, Goodman & Gilman 14e, Katzung, BNF·Verified: 2026-05-10 · House clinical team