Amitriptyline
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Drug reference
methoxamine
Selective α1 agonist · Pressor agent
Selective α1 agonistPressor agent
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
- AmitriptylineSevereDatabaseDDInter
- AmoxapineSevereDatabaseDDInter
- ClomipramineSevereDatabaseDDInter
- DesipramineSevereDatabaseDDInter
Mechanism
Methoxamine is a selective α1 agonist with no β actions and weak β blocking action. It closely resembles phenylephrine.
Indications
Pressor agent
Dosing
- Adult
- 10–20 mg i.m.; 3–5 mg slow i.v. inj
Drug interactions
Amoxapine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Clomipramine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Desipramine
Severe
Database
Clinical effect not specified
Source: DDInter
Dihydroergotamine
Severe
Database
Clinical effect not specified
Source: DDInter
Doxepin
Severe
Database
Clinical effect not specified
Source: DDInter
Ergotamine Tartrate
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Imipramine
Severe
Database
Clinical effect not specified
Source: DDInter
Linezolid
Severe
Database
Clinical effect not specified
Source: DDInter
Methylergometrine
Severe
Database
Clinical effect not specified
Source: DDInter
Methysergide
Severe
Database
Clinical effect not specified
Source: DDInter
Nortriptyline
Severe
Database
Clinical effect not specified
Source: DDInter
Related guidelines
Ask House about methoxamine
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Sources: KD Tripathi 7e·Verified: 2026-05-10 · House clinical team