Adalimumab
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Drug reference
monomethyl fumarate
Immunomodulator (fumarate) · Immunomodulator
Immunomodulator (fumarate)Immunomodulator
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
- AdalimumabSevereDatabaseDDInter
- BaricitinibSevereDatabaseDDInter
- CertolizumabSevereDatabaseDDInter
- CladribineSevereDatabaseDDInter
Mechanism
Active form of dimethyl fumarate and diroximel fumarate. Activator of nrf2 that mediates an antioxidative stress response. Also a nicotinic acid receptor agonist, contributing to cutaneous flushing.
Indications
relapsing-remitting mssecondary progressive ms in adults
Side effects
Common
cutaneous flushinggi side effects
Serious
- lymphopenia
- pml
- opportunistic infections (viral, fungal, bacterial)
Drug interactions
Baricitinib
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Certolizumab
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Cladribine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Dimethyl Fumarate
Severe
Database
Clinical effect not specified
Source: DDInter
Diroximel Fumarate
Severe
Database
Clinical effect not specified
Source: DDInter
Etanercept
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Fingolimod
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Golimumab
Severe
Database
Clinical effect not specified
Source: DDInter
Infliximab
Severe
Database
Clinical effect not specified
Source: DDInter
Leflunomide
Severe
Database
Clinical effect not specified
Source: DDInter
Lomitapide
Severe
Database
Clinical effect not specified
Source: DDInter
Related guidelines
Other Immunomodulator (fumarate) drugs
Ask House about monomethyl fumarate
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team