Dihydroergotamine
Severe
Database
Clinical effect not specified
Source: DDInter
Drug reference
naphazoline
Alpha adrenergic agonist · Autonomic agent
Alpha adrenergic agonistAutonomic agent
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
5 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
- DihydroergotamineSevereDatabaseDDInter
- ErgometrineSevereDatabaseDDInter
- Ergotamine TartrateSevereDatabaseDDInter
- MethylergometrineSevereDatabaseDDInter
Mechanism
Not yet extracted
Indications
decongestantallergic conjunctivitis (in combination)Nasal decongestant
Dosing
- Adult
- 0.1% topical in nose
Pharmacokinetics
Duration
12 hours
Side effects
Common
Initial stinging sensationAfter-congestion (prolonged use)Mucosal ciliary function impairment (prolonged use)Atrophic rhinitis (prolonged use)Anosmia (prolonged use)
Serious
- CNS depression
- coma
- marked reduction in body temperature (in infants)
- CNS depression (from systemic absorption)
- Rise in BP (from systemic absorption)
Drug interactions
Ergometrine
Severe
Database
Clinical effect not specified
Source: DDInter
Ergotamine Tartrate
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Methylergometrine
Severe
Database
Clinical effect not specified
Source: DDInter
Methysergide
Severe
Database
Clinical effect not specified
Source: DDInter
Moclobemide
Moderate
Textbook
Systemic effects including rise in BP.
These drugs should be used cautiously in those receiving MAO inhibitors.
Source: KDT 7e · p136
Isocarboxazid
Moderate
Database
Systemic effects including rise in BP.
These drugs should be used cautiously in those receiving MAO inhibitors.
Source: DDInter
Phenelzine
Moderate
Database
Systemic effects including rise in BP.
These drugs should be used cautiously in those receiving MAO inhibitors.
Source: DDInter
Procarbazine
Moderate
Database
Systemic effects including rise in BP.
These drugs should be used cautiously in those receiving MAO inhibitors.
Source: DDInter
Rasagiline
Moderate
Database
Systemic effects including rise in BP.
These drugs should be used cautiously in those receiving MAO inhibitors.
Source: DDInter
Selegiline
Moderate
Database
Systemic effects including rise in BP.
These drugs should be used cautiously in those receiving MAO inhibitors.
Source: DDInter
Tranylcypromine
Moderate
Database
Systemic effects including rise in BP.
These drugs should be used cautiously in those receiving MAO inhibitors.
Source: DDInter
Related guidelines
Other Alpha adrenergic agonist drugs
Ask House about naphazoline
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e, Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team