House
Create account
Drug reference directory
Drug reference

netupitant

Neurokinin 1 (NK1) receptor antagonist · Antiemetic

Neurokinin 1 (NK1) receptor antagonistAntiemeticATC A04AD15
CDSCO approvedATC A04AD15
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
  • AcalabrutinibSevereDatabaseDDInter
  • ApalutamideSevereDatabaseDDInter
  • AvanafilSevereDatabaseDDInter
  • AvapritinibSevereDatabaseDDInter

Mechanism

Netupitant is a neurokinin 1 (NK1) receptor antagonist. It blocks the binding of substance P at NK1 receptors, which are involved in chemotherapy-induced nausea and vomiting.

Indications

Prevention of chemotherapy-induced nausea and vomiting (acute and delayed, in combination with palonosetron)

Dosing

Adult
Single capsule (in combination with palonosetron) administered orally about 1 h prior to chemotherapy (with dexamethasone).

Pharmacokinetics

Half-life
About 80 h
Metabolism
Extensively metabolized by CYP3A4 (major) and CYP2C9 and CYP2D6 (minor) to active metabolites
Excretion
In feces and urine

Side effects

Common
HeadacheConstipationFatigue
Serious
  • Serotonin syndrome

Drug interactions

Acalabrutinib
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Apalutamide
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Avanafil
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Avapritinib
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Bosutinib
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Brexpiprazole
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Brigatinib
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Butorphanol
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Carbamazepine
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Cilostazol
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Cobimetinib
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Colchicine
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Related guidelines

Stroke and TIA — secondary prevention
AHA · Neurology · 2021
Tobacco-related cancer prevention
ICMR · Oncology · 2021
Cardiovascular disease prevention
ESC · Cardiology · 2021
Primary prevention of cardiovascular disease
AHA · Cardiology · 2019
Infective endocarditis prevention
ADA_DENTAL · Dentistry · 2015

Ask House about netupitant

Continue into a citation-backed clinical answer with the drug context already attached.

Open in workspaceAsk House about this drug

Textbook-sourced·Sources: Goodman & Gilman 14e·Updated: 2026-05-10