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netupitant

Neurokinin 1 (NK1) receptor antagonist · Antiemetic

Neurokinin 1 (NK1) receptor antagonistAntiemeticATC A04AD15
CDSCO approvedATC A04AD15
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
  • AcalabrutinibSevereDatabaseDDInter
  • ApalutamideSevereDatabaseDDInter
  • AvanafilSevereDatabaseDDInter
  • AvapritinibSevereDatabaseDDInter

Mechanism

Netupitant is a neurokinin 1 (NK1) receptor antagonist. It blocks the binding of substance P at NK1 receptors, which are involved in chemotherapy-induced nausea and vomiting.

Indications

Prevention of chemotherapy-induced nausea and vomiting (acute and delayed, in combination with palonosetron)

Dosing

Adult
Single capsule (in combination with palonosetron) administered orally about 1 h prior to chemotherapy (with dexamethasone).

Pharmacokinetics

Half-life
About 80 h
Metabolism
Extensively metabolized by CYP3A4 (major) and CYP2C9 and CYP2D6 (minor) to active metabolites
Excretion
In feces and urine

Side effects

Common
HeadacheConstipationFatigue
Serious
  • Serotonin syndrome

Drug interactions

Acalabrutinib
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Apalutamide
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Avanafil
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Avapritinib
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Bosutinib
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Brexpiprazole
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Brigatinib
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Butorphanol
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Carbamazepine
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Cilostazol
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Cobimetinib
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Colchicine
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Related guidelines

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AHA · Neurology · 2021
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ICMR · Oncology · 2021
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ESC · Cardiology · 2021
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AHA · Cardiology · 2019
Infective endocarditis prevention
ADA_DENTAL · Dentistry · 2015

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Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team