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nilutamide

Androgen Receptor Antagonist · Antiandrogen; Prostate cancer agent (adjuvant for metastatic prostate cancer); Androgen receptor binding inhibitor; Adrenal androgen action blocker

Androgen Receptor AntagonistAntiandrogen; Prostate cancer agent (adjuvant for metastatic prostate cancer); Androgen receptor binding inhibitor; Adrenal androgen action blockerATC null
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
X
FDA category + note
Top interactionssee all 12 →
  • AmiodaroneSevereDatabaseDDInter
  • AmisulprideSevereDatabaseDDInter
  • AnagrelideSevereDatabaseDDInter
  • Arsenic TrioxideSevereDatabaseDDInter

Mechanism

Not yet extracted

Indications

All forms of advanced prostate cancer

Dosing

Adult
Oral once daily.

Pharmacokinetics

Half-life
Elimination half-life of 45 hours.
Excretion
Metabolized to five products that are all excreted in the urine.

Side effects

Common
Mild nauseaAlcohol intolerance (5%–20%)Diminished ocular adaptation to darkness (25%–40%)
Serious
  • Interstitial pneumonitis (rarely)

Pregnancy & lactation

Pregnancy

X

Drug interactions

Amiodarone
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Amisulpride
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Anagrelide
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Arsenic Trioxide
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Bedaquiline
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Bepridil
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Cabozantinib
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Ceritinib
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Cisapride
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Citalopram
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Clozapine
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Crizotinib
Severe
Database

Clinical effect not specified

Source: DDInter

Related guidelines

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ESMO · Oncology · 2024
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MOHFW · Cardiology · 2024
Breast cancer
ICMR · Oncology · 2022
Cervical cancer screening and management
ICMR · Oncology · 2022
Tobacco-related cancer prevention
ICMR · Oncology · 2021

Other Androgen Receptor Antagonist drugs

darolutamide
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Textbook-sourced·Sources: Goodman & Gilman 14e·Updated: 2026-05-10