Cidofovir
Severe
Database
Clinical effect not specified
Source: DDInter
Drug reference
Olsalazine
Aminosalicylate · Agent for Inflammatory Bowel Disease
Also known as Olsalazine sodium
AminosalicylateAgent for Inflammatory Bowel Disease
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
C
FDA category + note
Top interactionssee all 12 →
- CidofovirSevereDatabaseDDInter
- DeferasiroxSevereDatabaseDDInter
- DiatrizoateSevereDatabaseDDInter
- Human Cytomegalovirus Immune GlobulinSevereDatabaseDDInter
Mechanism
Olsalazine is a dimer of 5-aminosalicylic acid (5-ASA) that cleaves in the lower bowel, releasing the active component 5-ASA. 5-ASA exerts its therapeutic effects locally in the gastrointestinal tract.
Indications
Treatment of acute attack of mild ulcerative colitisMaintenance of remission of mild ulcerative colitisInflammatory bowel diseaseinduction and maintenance of remission in mild-to-moderate ulcerative colitissevere ulcerative colitis (in combination with glucocorticoids)
Dosing
- Adult
- Treatment of acute attack of mild ulcerative colitis: 1 g daily in divided doses, to be taken after meals. Increase if necessary up to 3 g daily in divided doses over 1 week (max. 1 g per dose).
- Max dose
- 3 g daily
Pharmacokinetics
Metabolism
Cleaves in the lower bowel to release 5-aminosalicylic acid (5-ASA).
Side effects
Common
Photosensitivitydiarrhea (10%–20% of patients)headachedyspepsiaskin rash
Serious
- Blood disorders
- Lupus-like syndrome
- nephrotoxicity (interstitial nephritis)
- pancreatitis
- pericarditis
- pleuritis
Pregnancy & lactation
Pregnancy
C
Drug interactions
Deferasirox
Severe
Database
Clinical effect not specified
Source: DDInter
Diatrizoate
Severe
Database
Clinical effect not specified
Source: DDInter
Human Cytomegalovirus Immune Globulin
Severe
Database
Clinical effect not specified
Source: DDInter
Inotersen
Severe
Database
Clinical effect not specified
Source: DDInter
Iodipamide
Severe
Database
Clinical effect not specified
Source: DDInter
Iodixanol
Severe
Database
Clinical effect not specified
Source: DDInter
Iohexol
Severe
Database
Clinical effect not specified
Source: DDInter
Iopamidol
Severe
Database
Clinical effect not specified
Source: DDInter
Iopromide
Severe
Database
Clinical effect not specified
Source: DDInter
Iothalamic Acid
Severe
Database
Clinical effect not specified
Source: DDInter
Ioversol
Severe
Database
Clinical effect not specified
Source: DDInter
Related guidelines
Inflammatory bowel disease
OTHER · Gastroenterology · 2015
Preventive care in inflammatory bowel disease
ACG · Gastroenterology · 2025
Induction of labour
FOGSI · Obstetrics & Gynaecology · 2019
Coeliac disease
OTHER · Gastroenterology · 2016
Chronic kidney disease — assessment and management
KDIGO · Nephrology · 2024
Other Aminosalicylate drugs
Ask House about Olsalazine
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Goodman & Gilman 14e, Katzung, BNF, Nelson·Verified: 2026-05-10 · House clinical team