Drug reference
onabotulinumtoxina
Neurotoxin; Smooth muscle relaxant · Gastrointestinal motility agent
Neurotoxin; Smooth muscle relaxantGastrointestinal motility agentATC M03AX01
CDSCO approvedATC M03AX01
EXCRETION
—
not curated
INTERACTIONS
—
none in our sources
PREGNANCY
—
not curated
Mechanism
OnabotulinumtoxinA inhibits acetylcholine (ACh) release from nerve endings, leading to partial paralysis of the sphincter muscle. This can improve symptoms and esophageal clearance in conditions like achalasia.
Indications
Achalasia of the esophagus
Dosing
- Adult
- 100 units injected directly into the lower esophageal sphincter in four equal portions (for achalasia)
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Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team