Drug reference

ormeloxifene

Non-steroidal selective estrogen receptor modulator (SERM) · Oral Contraceptive, Dysfunctional Uterine Bleeding Agent

Non-steroidal selective estrogen receptor modulator (SERM)Oral Contraceptive, Dysfunctional Uterine Bleeding Agent

CDSCO approved

EXCRETION

—

not curated

INTERACTIONS

—

none in our sources

PREGNANCY

FDA category + note

Mechanism

It has predominant estrogen antagonistic action in uterus and breast with little action on vaginal epithelium and cervical mucus. Endometrial proliferation is suppressed by down regulation of endometrial ER. Contraceptive action is probably due to utero-embyonic asynchrony and failure of implantation. Pituitary, ovarian and other endocrine functions remain practically unaffected.

Indications

Oral contraceptiveDysfunctional uterine bleeding

Dosing

Adult: For contraception: 30 mg twice a week for 12 weeks followed by once a week. For dysfunctional uterine bleeding: 60 mg twice a week for 12 weeks, then once a week for 12 weeks.