Drug reference

osilodrostat

Selective CYP11B1 and CYP11B2 inhibitor, steroidogenesis inhibitor · Steroidogenesis inhibitor

Selective CYP11B1 and CYP11B2 inhibitor, steroidogenesis inhibitorSteroidogenesis inhibitor

CDSCO approved

EXCRETION

—

not curated

INTERACTIONS

12 major

SEVERE in our sources

PREGNANCY

—

not curated

Top interactionssee all 12 →

AmiodaroneSevereDatabaseDDInter
AmisulprideSevereDatabaseDDInter
AmprenavirSevereDatabaseDDInter
AnagrelideSevereDatabaseDDInter

Mechanism

A nonsteroidal, orally available, selective inhibitor of CYP11B1 and CYP11B2, thereby reducing cortisol synthesis.

Indications

cushing disease (in patients who are not surgical candidates or who have recurrent disease)

Side effects

Serious

adrenal insufficiency
adverse effects due to adrenal hormone precursors

Drug interactions

Amiodarone

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Amisulpride

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Amprenavir

Severe

Database

Drug interaction classified as: metabolism

Source: DDInter

Anagrelide

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Apalutamide

Severe

Database

Drug interaction classified as: metabolism

Source: DDInter

Arsenic Trioxide

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Atazanavir

Severe

Database

Drug interaction classified as: metabolism

Source: DDInter

Bedaquiline

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Bepridil

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Boceprevir

Severe

Database

Drug interaction classified as: metabolism

Source: DDInter

Cabozantinib

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Carbamazepine

Severe

Database

Drug interaction classified as: metabolism

Source: DDInter

Related guidelines

Coeliac disease

OTHER · Gastroenterology · 2016

Inflammatory bowel disease

OTHER · Gastroenterology · 2015

Chronic kidney disease — assessment and management

KDIGO · Nephrology · 2024

Chronic kidney disease — assessment and management

NICE · Nephrology · 2021

Diabetes management in chronic kidney disease

KDIGO · Nephrology · 2022

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Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team