Drug reference
oxethazaine
Local Anaesthetic
Local Anaesthetic
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
—
none in our sources
PREGNANCY
—
not curated
Mechanism
Oxethazaine is a potent topical anaesthetic that ionizes to a very small extent even at low pH values. This property allows it to effectively anaesthetise gastric mucosa despite the acidity of the medium.
Indications
Gastritis (symptomatic relief)Drug-induced gastric irritation (symptomatic relief)Gastroesophageal reflux (symptomatic relief)Heartburn of pregnancy (symptomatic relief)
Dosing
- Adult
- 5–10 ml orally (0.2% suspension); maximum 100 mg/day.
Side effects
Common
Dizziness (doses exceeding 100 mg/day)Drowsiness (doses exceeding 100 mg/day)
Related guidelines
Gastro-oesophageal reflux disease
ISG · Gastroenterology · 2022
Gastric premalignant conditions
ACG · Gastroenterology · 2025
Iron deficiency anaemia in pregnancy
ICMR · Obstetrics & Gynaecology · 2022
Hypertensive disorders of pregnancy
FOGSI · Obstetrics & Gynaecology · 2019
Iron deficiency anaemia in pregnancy
FOGSI · Obstetrics & Gynaecology · 2017
Ask House about oxethazaine
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Textbook-sourced·Sources: KD Tripathi 7e·Updated: 2026-05-10