Alprazolam
Severe
Database
Drug interaction classified as: synergy.
Source: DDInter
Drug reference
oxymorphone
Mu-opioid receptor agonist · Analgesic
Mu-opioid receptor agonistAnalgesic
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
- AlprazolamSevereDatabaseDDInter
- AlvimopanSevereDatabaseDDInter
- AmobarbitalSevereDatabaseDDInter
- AripiprazoleSevereDatabaseDDInter
Mechanism
Oxymorphone is a potent mu-opioid receptor agonist.
Indications
analgesia
Dosing
- Adult
- Oral: 5 mg/3–4 h; Parenteral: 1 mg/3–4 h
- Pediatric
- Oral: 0.1 mg/kg/3–4 h
Pharmacokinetics
Duration
3–4 h
Metabolism
Extensively metabolized in the liver to 3- and 6-glucuronides
Drug interactions
Alvimopan
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Amobarbital
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Aripiprazole
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Asenapine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Baclofen
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Benzhydrocodone
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Brexpiprazole
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Buprenorphine
Severe
Database
Drug interaction classified as: synergy.
Source: DDInter
Bupropion
Severe
Database
Drug interaction classified as: synergy.
Source: DDInter
Buspirone
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Butabarbital
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Related guidelines
Ask House about oxymorphone
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team