Drug reference

pancrelipase

Pancreatic enzyme replacement · Digestive enzyme supplement

Pancreatic enzyme replacementDigestive enzyme supplementATC A09AA02

CDSCO approvedATC A09AA02

EXCRETION

—

not curated

INTERACTIONS

—

none in our sources

PREGNANCY

—

not curated

Mechanism

Pancrelipase provides exogenous lipase, amylase, and proteases to replace deficient pancreatic enzyme production. This aids in the digestion of fats, proteins, and carbohydrates in the duodenum, preventing malabsorption.

Indications

Fat malabsorption (steatorrhea) and protein maldigestion due to pancreatic exocrine insufficiency (e.g., chronic pancreatitis, pancreatectomy, cystic fibrosis)Pain associated with chronic pancreatitis (evidence equivocal)

Dosing

Adult: Initial dose of lipase: 500 USP units/kg per meal, increasing up to 2500 USP units/kg per meal. Maximum recommended dose: generally not to exceed 2500 USP units/kg per meal or 10,000 USP unit/kg per day.
Pediatric: Children younger than 4 years have increased needs for lipase and initial doses are higher. Special dosing regimens for breastfeeding infants.