Drug reference
pcp
NMDA receptor antagonist · Hallucinogen
NMDA receptor antagonistHallucinogen
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
—
none in our sources
PREGNANCY
—
not curated
Mechanism
PCP is an NMDA receptor antagonist that blocks NMDA-type glutamate receptors in regions mediating cognition and emotion.
Side effects
Common
Emotional withdrawalConcrete thinkingBizarre responses to projective testingCatatonic posturingAggressive behaviorHostile behaviorAssaultive behaviorStuporComaMuscular rigidityHyperthermiaElevated blood pressureEnlarged, nonreactive pupils
Serious
- Rhabdomyolysis
- Hallucinogen-induced psychosis
- Transition to schizophrenia
- Overdose
Ask House about pcp
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team