Allopurinol
Severe
Database
Drug interaction classified as: others
Source: DDInter
Drug reference
pegloticase
Uricase (urate oxidase), Pegylated · Antigout, Urate-lowering
Uricase (urate oxidase), PegylatedAntigout, Urate-lowering
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
3 major
SEVERE in our sources
PREGNANCY
B
FDA category + note
Top interactions
- AllopurinolSevereDatabaseDDInter
- ProbenecidSevereDatabaseDDInter
- SulfinpyrazoneSevereDatabaseDDInter
Mechanism
Pegloticase is a pegylated uricase that catalyzes the enzymatic oxidation of uric acid into allantoin, which is a more soluble and inactive metabolite. The recombinant enzyme is based on porcine uricase.
Indications
Severe, treatment-refractory, chronic goutGout when use of other urate-lowering therapies is contraindicated
Dosing
- Adult
- Administered by infusion every 2 weeks.
Side effects
Common
Bruising (11%)Urticaria (11%)Nausea (11%)Gout flare during early therapy (74%)Chest pain (6%)VomitingConstipationDiarrheaErythemaPruritus
Serious
- Antibody development against the drug (in nearly 90% of people), associated with loss of urate-lowering effect and elevated risk for infusion reactions
- Anaphylactic reactions
- Hemolysis in G6PD-deficient patients
Pregnancy & lactation
Pregnancy
B
Drug interactions
Probenecid
Severe
Database
Clinical effect not specified
Source: DDInter
Sulfinpyrazone
Severe
Database
Clinical effect not specified
Source: DDInter
6 additional low-confidence interactions hidden — those rows lack a documented mechanism or management plan in our sources.
Related guidelines
Ask House about pegloticase
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Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team