Bupropion
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Drug reference
pemoline
CNS stimulant · CNS Stimulant, ADHD Agent
CNS stimulantCNS Stimulant, ADHD AgentATC N06BA05
CDSCO approvedATC N06BA05
EXCRETION
—
not curated
INTERACTIONS
10 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 10 →
- BupropionSevereDatabaseDDInter
- EsketamineSevereDatabaseDDInter
- IohexolSevereDatabaseDDInter
- IopamidolSevereDatabaseDDInter
Mechanism
Pemoline elicits similar changes in CNS function to methylphenidate, with minimal effects on the cardiovascular system.
Indications
attention-deficit/hyperactivity disorder (ADHD)Depression in terminally ill patientsPatients with intestinal obstruction or dysphagia (due to buccal absorption)
Dosing
- Adult
- 18.75 mg in the morning and at noon
Pharmacokinetics
Half-life
long (permits once-daily dosing)
Contraindications
- prolonged periods without liver function monitoring
Side effects
Serious
- severe hepatic failure
Drug interactions
Esketamine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Iohexol
Severe
Database
Clinical effect not specified
Source: DDInter
Iopamidol
Severe
Database
Clinical effect not specified
Source: DDInter
Leflunomide
Severe
Database
Clinical effect not specified
Source: DDInter
Mipomersen
Severe
Database
Clinical effect not specified
Source: DDInter
Pexidartinib
Severe
Database
Clinical effect not specified
Source: DDInter
Pimozide
Severe
Database
Clinical effect not specified
Source: DDInter
Teriflunomide
Severe
Database
Clinical effect not specified
Source: DDInter
Tramadol
Severe
Database
Clinical effect not specified
Source: DDInter
2 additional low-confidence interactions hidden — those rows lack a documented mechanism or management plan in our sources.
Related guidelines
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Sources: Goodman & Gilman 14e, Harrison 22e·Verified: 2026-05-10 · House clinical team