Drug reference

pentoxiphylline

Phosphodiesterase inhibitor, Rheologic agent · Peripheral vasodilator

Phosphodiesterase inhibitor, Rheologic agentPeripheral vasodilator

CDSCO approved

EXCRETION

—

not curated

INTERACTIONS

—

none in our sources

PREGNANCY

—

not curated

Mechanism

Weak phosphodiesterase (PDE) inhibitor. Increases blood flow in ischaemic areas by reducing whole blood viscosity and by improving flexibility of RBCs (rheological action).

Indications

Intermittent claudication (due to occlusive vascular disease like Buerger’s disease)Trophic leg ulcersTransient ischaemic attacks (TIAs)Nonhaemorrhagic strokeChronic cerebrovascular insufficiency