Drug reference
perchlorate
ionic inhibitor, antithyroid drug · antithyroid
ionic inhibitor, antithyroid drugantithyroid
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
—
none in our sources
PREGNANCY
—
not curated
Mechanism
Blocks the entrance of iodide into the thyroid by competitively inhibiting the sodium iodide symporter (NIS). Can itself be transported by NIS into the thyroid gland.
Indications
control hyperthyroidismdiagnostic test of iodide organification (to "discharge" inorganic iodide from the thyroid gland)enhance the response to thioamides in refractory Graves disease (e.g., that associated with amiodarone)
Dosing
- Adult
- 750 mg daily has been used in the treatment of Graves disease.
Contraindications
- excessive amounts (2–3 g daily) due to risk of fatal aplastic anemia
Side effects
Serious
- fatal aplastic anemia (with excessive amounts)
Related guidelines
Other ionic inhibitor, antithyroid drug drugs
Ask House about perchlorate
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team