Methotrexate
Severe
Database
.
Source: DDInter
Drug reference
piperacillin
Penicillin (Antipseudomonal Penicillin) · Antibacterial, β-Lactam Antibiotic, Cell Wall Synthesis Inhibitor (Antipseudomonal)
Penicillin (Antipseudomonal Penicillin)Antibacterial, β-Lactam Antibiotic, Cell Wall Synthesis Inhibitor (Antipseudomonal)ATC null
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
2 major
SEVERE in our sources
PREGNANCY
X
FDA category + note
Top interactionssee all 10 →
- MethotrexateSevereDatabaseDDInter
- VancomycinSevereDatabaseDDInter
Mechanism
Not yet extracted
Indications
Nosocomial infectionsPneumoniaIntra-abdominal infectionsUrinary tract infectionsBacteremiasInfections following burnsMixed intra-abdominal infectionsPseudomonas (UTI, enteritis)Serious gram-negative infections in neutropenic, immunocompromised, or burn patientsserious Pseudomonas infection (in patients with indwelling catheters or chronic urinary obstruction, and in hospitalized patients based on sensitivity)
Pharmacokinetics
Half-life
1 hr
Side effects
Common
impaired hemostasis (defective platelet aggregation)Gastrointestinal side effects (e.g., diarrhea)
Serious
- Hypersensitivity reactions (rash to anaphylaxis)
- Serum sickness
- Stevens-Johnson syndrome
- Nephropathy
- Hematologic reactions (neutropenia, prolonged use)
- Neurotoxicity (seizure, high doses, renal impairment)
Pregnancy & lactation
Pregnancy
X
Drug interactions
Vancomycin
Severe
Database
.
Source: DDInter
Azithromycin
Moderate
Textbook-cited
Reduced antibacterial efficacy; therapeutic failure.
Avoid concurrent use of bacteriostatic and bactericidal antibiotics
Source: KDT 7e · p949
Chloramphenicol
Moderate
Textbook-cited
Reduced antibacterial efficacy; therapeutic failure
Avoid concurrent use of bacteriostatic and bactericidal antibiotics
Source: KDT 7e · p949
Clarithromycin
Moderate
Textbook-cited
Reduced antibacterial efficacy; therapeutic failure.
Avoid concurrent use of bacteriostatic and bactericidal antibiotics
Source: KDT 7e · p949
Clindamycin
Moderate
Textbook-cited
Reduced antibacterial efficacy; therapeutic failure.
Avoid concurrent use of bacteriostatic and bactericidal antibiotics
Source: KDT 7e · p949
Doxycycline
Moderate
Textbook-cited
Reduced antibacterial efficacy; therapeutic failure.
Avoid concurrent use of bacteriostatic and bactericidal antibiotics
Source: KDT 7e · p949
Erythromycin
Moderate
Textbook-cited
Reduced antibacterial efficacy; therapeutic failure.
Avoid concurrent use of bacteriostatic and bactericidal antibiotics
Source: KDT 7e · p949
Minocycline
Moderate
Textbook-cited
Reduced antibacterial efficacy; therapeutic failure.
Avoid concurrent use of bacteriostatic and bactericidal antibiotics
Source: KDT 7e · p949
Tetracycline
Moderate
Textbook-cited
Reduced antibacterial efficacy; therapeutic failure
Avoid concurrent use of bacteriostatic and bactericidal antibiotics
Source: KDT 7e · p949
2 additional low-confidence interactions hidden — those rows lack a documented mechanism or management plan in our sources.
Related guidelines
Ask House about piperacillin
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e, Goodman & Gilman 14e, Harrison 22e·Verified: 2026-05-10 · House clinical team