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plicamycin

Cytotoxic antibiotic · Antineoplastic agent

Cytotoxic antibioticAntineoplastic agent
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
  • AcalabrutinibSevereDatabaseDDInter
  • AdalimumabSevereDatabaseDDInter
  • ApixabanSevereDatabaseDDInter
  • AvapritinibSevereDatabaseDDInter

Mechanism

Decreases plasma Ca2+ concentrations by inhibiting bone resorption.

Indications

hypercalcemia

Dosing

Adult
15–25 μg/kg of body weight.

Side effects

Serious
  • high systemic toxicity

Drug interactions

Acalabrutinib
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Adalimumab
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Apixaban
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Avapritinib
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Baricitinib
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Betrixaban
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Cabozantinib
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Certolizumab
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Cladribine
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Clozapine
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Dalteparin
Severe
Database

Clinical effect not specified

Source: DDInter

Dasatinib
Severe
Database

Clinical effect not specified

Source: DDInter

Related guidelines

Acute dental pain and intraoral swelling
ADA_DENTAL · Dentistry · 2019
Infective endocarditis prevention
ADA_DENTAL · Dentistry · 2015
Community-acquired pneumonia
ICMR · Pulmonology · 2022
Extrapulmonary tuberculosis
ICMR · Infectious Diseases · 2022
Empirical antimicrobial use in common syndromes
ICMR · Infectious Diseases · 2019

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Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team