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Drug reference

propantheline

Semisynthetic anticholinergic, Quaternary compound · Antispasmodic, Antisecretory

Semisynthetic anticholinergic, Quaternary compoundAntispasmodic, Antisecretory
CDSCO approved
EXCRETION
not curated
INTERACTIONS
4 major
SEVERE in our sources
PREGNANCY
not curated
Top interactions
  • Potassium ChlorideSevereDatabaseDDInter
  • Potassium CitrateSevereDatabaseDDInter
  • TopiramateSevereDatabaseDDInter
  • ZonisamideSevereDatabaseDDInter

Mechanism

Propantheline is an anticholinergic drug with some ganglion blocking activity. It blocks muscarinic receptors, reduces gastric secretion, and delays gastric emptying.

Indications

Peptic ulcer (use declined)Gastritis

Dosing

Adult
15–30 mg oral

Pharmacokinetics

Duration
6–8 hours

Side effects

Common
Mild side effects

Drug interactions

Potassium Chloride
Severe
Database

Clinical effect not specified

Source: DDInter

Potassium Citrate
Severe
Database

Clinical effect not specified

Source: DDInter

Topiramate
Severe
Database

Clinical effect not specified

Source: DDInter

Zonisamide
Severe
Database

Clinical effect not specified

Source: DDInter

8 additional low-confidence interactions hidden — those rows lack a documented mechanism or management plan in our sources.

Related guidelines

Other Semisynthetic anticholinergic, Quaternary compound drugs

Ask House about propantheline

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Sources: KD Tripathi 7e·Verified: 2026-05-10 · House clinical team