Clozapine
Moderate
Textbook
Intestinal obstruction (inspissation).
Avoid.
Source: G&G 14e · p373
Hydrophilic Colloid · Laxative
Psyllium is a hydrophilic colloid and bulk-forming agent that enhances the retention of intraluminal fluid. It resists enzymatic digestion and reaches the colon largely unchanged, where it is fermented by colonic bacteria. This action increases stool water content and propulsive contractions in the colon, while decreasing overall transit time, leading to softened and bulkier feces.
because of increased fetal loss in guinea pigs. Lubiprostone may cause
Intestinal obstruction (inspissation).
Avoid.
Source: G&G 14e · p373
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e, Goodman & Gilman 14e, Katzung·Verified: 2026-05-13 · House clinical team