Piperazine
Moderate
Textbook
Reduced efficacy of pyrantel against worms.
Avoid concomitant use.
Source: KDT 7e · p852
Drug reference
pyrantel
null · Anthelmintic
nullAnthelminticATC null
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
—
none in our sources
PREGNANCY
X
FDA category + note
Mechanism
null
Pharmacokinetics
Bioavailability
poorly absorbed from the intestine
Excretion
>85% of the dose is passed unaltered in feces; absorbed portion metabolized and excreted in urine
Side effects
Common
gi disturbancesheadachedizzinesselevated aminotransferases
Pregnancy & lactation
Pregnancy
X
Drug interactions
Other null drugs
Ask House about pyrantel
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e, Harrison 22e·Verified: 2026-05-10 · House clinical team