Drug reference

quinupristin-dalfopristin

Streptogramin · Antibacterial; Streptogramin

StreptograminAntibacterial; Streptogramin

CDSCO approved

EXCRETION

—

not curated

INTERACTIONS

—

none in our sources

PREGNANCY

FDA category + note

Mechanism

Dalfopristin binds to both the A and P sites of the peptidyl transferase center of the 23S rRNA of the 50S ribosome. Quinupristin binds to a site that overlaps the macrolide-binding site. Inhibits protein synthesis. Bactericidal. Concentration-dependent killing.

Side effects

Serious

Infusion-related reactions
Arthralgias
Myalgias (may be severe enough to warrant discontinuation)

Pregnancy & lactation

Pregnancy

Drug interactions

Substrates Of Cyp3a4

Moderate

Textbook

Increased levels of interacting drug.

Avoid concomitant administration if possible. If giving drugs concomitantly, monitor drug levels if possible.

Source: Harrison 22e · p1172

Ask House about quinupristin-dalfopristin

Continue into a citation-backed clinical answer with the drug context already attached.

Open in workspace Ask House about this drug

Sources: Harrison 22e·Verified: 2026-05-10 · House clinical team