Racecadotril

Racecadotril is a prodrug that is rapidly converted to its active metabolite, thiorphan, an enkephalinase inhibitor. Thiorphan prevents the degradation of endogenous enkephalins, which in turn reinforces their effects on delta-opioid receptors to inhibit intestinal secretion, thereby producing an anti-diarrheal effect.

Adult

diarrhoea in adults and children over 3 months. There is insufficient evidence to recommend adsorbent preparations (such as kaolin) in acute diarrhoea. Antibacterial drugs for acute diarrhoea g Ciprofloxacin p. 590 is occasionally used for 3 prophylaxis against travellers’ diarrhoea, but routine use is not recommended. h See also Gastro-intestinal system infections, antibacterial therapy p. 535.…

Pediatric

1.5 mg/kg every 8 h with oral rehydration solution, until symptoms improve or for a maximum of 7 days.