Bucindolol
Contraindicated
Textbook
Reduced efficacy of ritodrine and potential for adverse cardiovascular effects.
Ritodrine should not be used if the mother is receiving beta blockers.
Source: KDT 7e · p333
Drug reference
Ritodrine
SABA · Tocolytic
SABATocolyticATC G02CA01
CDSCO approvedSchedule HATC G02CA01
EXCRETION
—
not curated
INTERACTIONS
12 major
incl. contraindicated
PREGNANCY
—
not curated
Top interactionssee all 12 →
- BucindololContraindicatedTextbookKDT 7e · p333
- CeliprololContraindicatedTextbookKDT 7e · p333
- Esmolol HydrochlorideContraindicatedTextbookKDT 7e · p333
- PenbutololContraindicatedTextbookKDT 7e · p333
Mechanism
Ritodrine is a beta2-selective adrenergic agonist. It stimulates beta2 adrenergic receptors, leading to relaxation of uterine smooth muscle.
Indications
Uterine relaxantuterine relaxant (to arrest premature labor)Uterine relaxant (to delay premature labour)Postpone labour
Dosing
- Adult
- hypotension; 15–60 mg TDS.. chronotropic effect on heart. Vasoconstriction (α EPHEDRINE HCl 15, 30 mg tab; SULFIDRIN 50 mg in. 1 1 ml inj, in ENDRINE 0.75% nasal drops.. i.v. infusion (0.2–1 mg/min) which is regulated. DOPAMINE, INTROPIN, DOPACARD 200 mg in 5 ml amp.
Pharmacokinetics
Bioavailability
30% (oral)
Metabolism
Conjugation to inactive forms
Excretion
90% in urine as inactive conjugates
Contraindications
- tocolytic (FDA boxed warning)
Side effects
Serious
- Maternal morbidity and mortality (due to cardiac and metabolic actions)
- Pulmonary edema
Drug interactions
Celiprolol
Contraindicated
Textbook
Reduced efficacy of ritodrine and potential for adverse cardiovascular effects.
Ritodrine should not be used if the mother is receiving beta blockers.
Source: KDT 7e · p333
Esmolol Hydrochloride
Contraindicated
Textbook
Reduced efficacy of ritodrine and potential for adverse cardiovascular effects.
Ritodrine should not be used if the mother is receiving beta blockers.
Source: KDT 7e · p333
Penbutolol
Contraindicated
Textbook
Reduced efficacy of ritodrine and potential for adverse cardiovascular effects.
Ritodrine should not be used if the mother is receiving beta blockers.
Source: KDT 7e · p333
Steroids
Contraindicated
Textbook
Increased risk of adverse metabolic effects like hyperglycemia.
Ritodrine should not be used if the mother is receiving steroids.
Source: KDT 7e · p333
Acebutolol
Severe
Database
Reduced efficacy of ritodrine and potential for adverse cardiovascular effects.
Ritodrine should not be used if the mother is receiving beta blockers.
Source: DDInter
Amiodarone
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Amisulpride
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Anagrelide
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Arsenic Trioxide
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Atenolol
Severe
Database
Reduced efficacy of ritodrine and potential for adverse cardiovascular effects.
Ritodrine should not be used if the mother is receiving beta blockers.
Source: DDInter
Bedaquiline
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Related guidelines
Other SABA drugs
Ask House about Ritodrine
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e, Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team