Meperidine
Contraindicated
Textbook
Stupor, rigidity, agitation, and hyperthermia.
Safinamide should not be given in combination with meperidine.
Source: G&G 14e · p419, p424
Drug reference
safinamide
MAO-B Inhibitor · Parkinson's disease treatment
MAO-B InhibitorParkinson's disease treatment
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
incl. contraindicated
PREGNANCY
—
not curated
Top interactionssee all 12 →
- MeperidineContraindicatedTextbookG&G 14e · p419, p424
- AlfentanilSevereDatabaseDDInter
- AmitriptylineSevereDatabaseDDInter
- AmoxapineSevereDatabaseDDInter
Mechanism
Selectively inhibits monoamine oxidase B (MAO-B), which can increase dopamine (DA) levels.
Indications
Parkinson's diseaseAdjunctive therapy to levodopa for off periods in PD
Drug interactions
Alfentanil
Severe
Database
Drug interaction classified as: others
Source: DDInter
Amitriptyline
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Amoxapine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Amphetamine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Apraclonidine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Berotralstat
Severe
Database
Drug interaction classified as: absorption
Source: DDInter
Bupropion
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Buspirone
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Clomipramine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Cyclobenzaprine
Severe
Database
Clinical effect not specified
Source: DDInter
Desipramine
Severe
Database
Clinical effect not specified
Source: DDInter
Related guidelines
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Ask House about safinamide
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team