Drug reference
salvia divinorum
KOR agonist · Hallucinogen
KOR agonistHallucinogen
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
—
none in our sources
PREGNANCY
—
not curated
Mechanism
Salvia divinorum contains salvinorin A, a potent naturally occurring hallucinogen which acts as a κ (kappa) opioid receptor (KOR) agonist and also has activity at the dopamine receptor.
Side effects
Common
Dysphoric (often considered by user)
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Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team