Alfentanil
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Drug reference
sibutramine
Noradrenergic/serotonergic anorectic · Anorectic
Noradrenergic/serotonergic anorecticAnorectic
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
- AlfentanilSevereDatabaseDDInter
- AlmotriptanSevereDatabaseDDInter
- AmitriptylineSevereDatabaseDDInter
- AmoxapineSevereDatabaseDDInter
Mechanism
Sibutramine inhibits both noradrenaline and 5-HT reuptake in the hypothalamus, suppressing appetite and probably increasing thermogenesis by activating adrenergic β3 mechanisms in adipose tissue.
Side effects
Serious
- Cardiovascular events
- Death
Drug interactions
Almotriptan
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Amitriptyline
Severe
Database
Drug interaction classified as: synergy.
Source: DDInter
Amoxapine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Amphetamine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Benzphetamine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Bupropion
Severe
Database
Drug interaction classified as: synergy.
Source: DDInter
Buspirone
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Citalopram
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Clomipramine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Desipramine
Severe
Database
Clinical effect not specified
Source: DDInter
Desvenlafaxine
Severe
Database
Clinical effect not specified
Source: DDInter
Ask House about sibutramine
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e·Verified: 2026-05-10 · House clinical team