Tolevamer
Severe
Database
Clinical effect not specified
Source: DDInter
Drug reference
sorbitol
Nondigestible alcohol; Osmotic agent · Laxative
Nondigestible alcohol; Osmotic agentLaxativeATC A06AD17
CDSCO approvedATC A06AD17
EXCRETION
—
not curated
INTERACTIONS
1 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactions
- TolevamerSevereDatabaseDDInter
Mechanism
Sorbitol is a nonabsorbable sugar/alcohol hydrolyzed in the colon to short-chain fatty acids, which stimulate colonic propulsive motility by osmotically drawing water into the lumen.
Indications
Constipation (including opioid-induced and vincristine-induced)Idiopathic chronic constipation
Pharmacokinetics
Onset
Effects may not be seen for 24 to 48 h
Side effects
Common
Abdominal discomfortDistentionFlatulence (usually subside with continued administration)
Drug interactions
1 additional low-confidence interaction hidden — those rows lack a documented mechanism or management plan in our sources.
Related guidelines
Ask House about sorbitol
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team