Clozapine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Drug reference
tagraxofusp
cytokine-cytotoxin conjugate (IL-3 and diphtheria toxin) · anticancer
cytokine-cytotoxin conjugate (IL-3 and diphtheria toxin)anticancer
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
7 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 7 →
- ClozapineSevereDatabaseDDInter
- DeferiproneSevereDatabaseDDInter
- LeflunomideSevereDatabaseDDInter
- LomitapideSevereDatabaseDDInter
Mechanism
Tagraxofusp is a fusion protein of human IL-3 and truncated diphtheria toxin that is directed to cells expressing the IL-3 receptor (CD123). It inhibits protein synthesis and causes cell death.
Indications
plasmacytoid dendritic cell neoplasm
Side effects
Serious
- capillary leak syndrome
Drug interactions
Deferiprone
Severe
Database
Clinical effect not specified
Source: DDInter
Leflunomide
Severe
Database
Clinical effect not specified
Source: DDInter
Lomitapide
Severe
Database
Clinical effect not specified
Source: DDInter
Mipomersen
Severe
Database
Clinical effect not specified
Source: DDInter
Pexidartinib
Severe
Database
Clinical effect not specified
Source: DDInter
Teriflunomide
Severe
Database
Clinical effect not specified
Source: DDInter
5 additional low-confidence interactions hidden — those rows lack a documented mechanism or management plan in our sources.
Ask House about tagraxofusp
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Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team