Alimemazine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Drug reference
Tetrabenazine
Antipsychotic · Agent for movement disorders
Also known as XENAZINE
AntipsychoticAgent for movement disorders
CDSCO approvedSchedule H
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
l BREAST FEEDING
FDA category + note
Top interactionssee all 12 →
- AlimemazineSevereDatabaseDDInter
- AmiodaroneSevereDatabaseDDInter
- AmisulprideSevereDatabaseDDInter
- AmoxapineSevereDatabaseDDInter
Mechanism
Tetrabenazine is a vesicular monoamine transporter 2 (VMAT2) inhibitor. It acts by depleting vesicular stores of dopamine in the central nervous system.
Indications
Chorea associated with Huntington’s diseaseSymptomatic treatment of Huntington’s diseaseTreatment of chorea associated with Huntington’s diseaseinvoluntary movement disordersHuntington’s choreatardive dyskinesiaTreatment of chorea associated with HD
Dosing
- Adult
- ▶ BY MOUTH 4.1 Dystonias and other involuntary movements Nervous system 4 Essential tremor, chorea, tics, and related disorders Drugs used in essential tremor, chorea, tics, and related disorders Tetrabenazine p. 425 is mainly used to control movement disorders in Huntington’s chorea and related disorders.…
Side effects
Serious
- hypotension
- depression with suicidality
- parkinsonism
Pregnancy & lactation
Pregnancy
l BREAST FEEDING
Drug interactions
Amiodarone
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Amisulpride
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Amoxapine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Anagrelide
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Aripiprazole
Severe
Database
Drug interaction classified as: synergy.
Source: DDInter
Arsenic Trioxide
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Asenapine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Bedaquiline
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Bepridil
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Brexpiprazole
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Bupropion
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Related guidelines
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OTHER · Gastroenterology · 2016
Inflammatory bowel disease
OTHER · Gastroenterology · 2015
Chronic kidney disease — assessment and management
KDIGO · Nephrology · 2024
Hypertensive disorders of pregnancy
FOGSI · Obstetrics & Gynaecology · 2019
Substance use disorders
NIMHANS · Psychiatry · 2022
Other Antipsychotic drugs
Ask House about Tetrabenazine
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Goodman & Gilman 14e, BNF·Verified: 2026-05-13 · House clinical team