Latex Condoms
Moderate
Database
Oil-based vehicle weakens latex
Avoid latex barriers during use
Source: Kimi deep-research + Cla
Drug reference
Tioconazole
Topical imidazole antifungal · Antifungal
START
VVC: 6.5% (300 mg) single intravaginal dose at bedtime
TYPICAL MAX
Single 300 mg vaginal dose; cream 1–2 times daily
STOP IF
Severe local reaction or hypersensitivity
WATCH
Symptomatic relief; consider partner treatment / hygiene
CDSCO approvedSchedule HATC G01AF08
KDIGO 2024 + manufacturer label
- ONSET
- 1d · symptoms
- PEAK
- 3d · max local
- t½
- 36s · topical
- DURATION
- 3d · single VVC
EXCRETION
Local — minimal systemic
route + CYP
INTERACTIONS
—
none in our sources
PREGNANCY
Considered acceptable in 2nd–3rd trimester; avoid 1st trimester unless essential.
FDA category + note
Mechanism
Inhibits fungal CYP51, disrupting ergosterol synthesis and damaging fungal cell membranes; broad activity against Candida and dermatophytes — used topically for vaginal candidiasis and tinea infections.
Indications
Vulvovaginal candidiasis (single-dose vaginal ointment)Tinea (cutaneous infections, regional)
Dosing
- Adult
- Vaginal: 6.5% ointment (300 mg) single intravaginal dose at bedtime. Topical: 1% cream applied 1–2 times daily for 2–4 weeks.
- Pediatric
- As adult topically.
- Renal adjustment
- No adjustment (topical).
- Hepatic adjustment
- No adjustment.
- Geriatric
- Standard topical use.
- Max dose
- Single 300 mg vaginal dose; topical 1–2 times daily
Pharmacokinetics
Onset
Symptom relief 24–72 h
Peak effect
Local — sustained while in contact
Duration
Single intravaginal dose for VVC
Half-life
Not applicable (topical; minimal systemic absorption)
Bioavailability
<10% systemic
Protein binding
Not applicable
Metabolism
Negligible systemic metabolism
Excretion
Local clearance
Contraindications
- Hypersensitivity to imidazole antifungals
Side effects
Common
Local burning / itchingVaginal irritation (vaginal preparation)Mild erythema
Serious
- Severe local hypersensitivity (rare)
Pregnancy & lactation
Pregnancy
Considered acceptable in 2nd–3rd trimester; avoid 1st trimester unless essential.
Lactation
Compatible (minimal systemic absorption).
Drug interactions
Other Topical Antifungals
Mild
Database
Duplicate therapy
Use one agent
Source: Kimi deep-research + Cla
Spermicides
Mild
Database
Possible reduced antifungal effect
Consider alternatives
Source: Kimi deep-research + Cla
Systemic Azole Antifungals
Mild
Database
Negligible additive systemic effect
Standard care
Source: Kimi deep-research + Cla
Topical Corticosteroids
Mild
Database
Combination products (intended for inflammatory tinea)
Standard combo where indicated
Source: Kimi deep-research + Cla
Related guidelines
Other Topical imidazole antifungal drugs
Ask House about Tioconazole
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Goodman & Gilman 14e, BNF·Verified: 2026-05-20 · House clinical team·Cockpit curated: 2026-05-20