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Drug reference

tissue plasminogen activator

Thrombolytic agent

Thrombolytic agent
CDSCO approved
EXCRETION
not curated
INTERACTIONS
none in our sources
PREGNANCY
not curated

Mechanism

Not yet extracted

Indications

evacuation of hyphemasubretinal clotnonclearing vitreous hemorrhagelyse blood clots obstructing a glaucoma filtration site (intracameral, off-label)

Side effects

Serious
  • bleeding

Drug interactions

Tranexamic Acid
Moderate
Database

Pharmacodynamic antagonism — tranexamic acid inhibits fibrinolysis while tPA promotes it. TXA may reduce tPA efficacy.

Avoid concurrent use if possible. If both needed (e.g., trauma with fibrinolysis), careful monitoring of coagulation parameters.

Source: Kimi deep-research + Cla

Related guidelines

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Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team