Drug reference

tlk199

Glutathione analogue

CDSCO approved

EXCRETION

—

not curated

INTERACTIONS

—

none in our sources

PREGNANCY

—

not curated

Mechanism

TLK199 is a prodrug that plasma esterases convert to TLK117, an active glutathione S-transferase (GST) inhibitor, which potentiates the toxicity of different anticancer agents.

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Textbook-sourced·Sources: Goodman & Gilman 14e·Updated: 2026-05-10