Vitamin E (α-tocopherol) acts as an antioxidant, protecting unsaturated lipids in cell membranes, coenzyme Q, and other structures from free radical oxidation damage, thereby curbing the generation of toxic peroxidation products. It may also have a specific structural role in biological membranes.
Supplemental doses for patients at risk of vitamin E deficiency (e.g., neuromuscular diseases, neurological defects in hepatobiliary disease, haemolytic anaemia)G-6-PD deficiency (to increase survival time of erythrocytes)Acanthocytosis (to normalize oxidative fragility of erythrocytes)Reduction of retrolental fibroplasia risk in premature infantsAdjunct with vitamin A to enhance its absorption and storage, and to reduce toxicity in hypervitaminosis ASymptomatic improvement in intermittent claudication, fibrocystic breast disease, and nocturnal muscle cramps
- Adult
- Supplemental doses: 10–30 mg/day. G-6-PD deficiency: 100 mg/day. Acanthocytosis: 100 mg/week i.m. Intermittent claudication, fibrocystic breast disease, nocturnal muscle cramps: 400–600 mg/day.
- Pediatric
- Retrolental fibroplasia in premature infants: 100 mg/kg/day oral.
Protein binding
Circulates in plasma in association with β-lipoprotein.
Metabolism
Circulates in plasma in association with β-lipoprotein, is stored in tissues.
Common
Abdominal crampsLoose motionsLethargy
Serious
- Creatinuria
- Impaired wound healing
Reduced effectiveness of iron therapy.
Monitor patients receiving concomitant vitamin E and iron therapy for the effectiveness of iron supplementation; adjustment of dosing schedules or amounts may be necessary.
Source: KDT 7e · p912