Drug reference

tolmetin

Acetic acid derivative · Anti-inflammatory, Analgesic

Acetic acid derivativeAnti-inflammatory, Analgesic

CDSCO approved

EXCRETION

—

not curated

INTERACTIONS

12 major

SEVERE in our sources

PREGNANCY

FDA category + note

Top interactionssee all 12 →

AcalabrutinibSevereDatabaseDDInter
AnisindioneSevereDatabaseDDInter
ApixabanSevereDatabaseDDInter
ArdeparinSevereDatabaseDDInter

Mechanism

Inhibits cyclooxygenase enzymes, reducing prostaglandin production.

Indications

Juvenile arthritisOsteoarthritisRheumatoid arthritisJuvenile rheumatoid arthritisAnkylosing spondylitis

Dosing

Adult: 400–600 mg 3 times/day
Pediatric: Children >2 y: 20 mg/kg/day in 3–4 divided doses

Pharmacokinetics

Onset

Peak plasma concentration (Cp) 20–60 min (food delays and decreases peak absorption)

Half-life

5 h

Bioavailability

Reduced when taken with food

Protein binding

99%

Metabolism

Carboxylate conjugates

Side effects

Common

Side effects (25%–40% develop, 5%–10% discontinue drug)Side effects occur in 25% to 40% of patientsGI side effects (most common, ~15%)CNS side effects (similar to indomethacin and aspirin, but less common and less severe)

Serious

Gastric ulceration

Pregnancy & lactation

Pregnancy