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Drug reference

tositumomab

radioimmunoconjugate, anti-CD20, 131I · anticancer

radioimmunoconjugate, anti-CD20, 131Ianticancer
CDSCO approved
EXCRETION
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
not curated
Top interactionssee all 12
  • AbciximabSevereDatabaseDDInter
  • AcalabrutinibSevereDatabaseDDInter
  • AdalimumabSevereDatabaseDDInter
  • AlteplaseSevereDatabaseDDInter

Mechanism

Tositumomab provides targeted delivery of radionuclides to tumor cells through a murine monoclonal antibody against CD20 conjugated with 131Iodine.

Indications

relapsed lymphoma

Side effects

Serious
  • antibody-related hypersensitivity
  • bone marrow suppression
  • secondary leukemias

Drug interactions

Abciximab
Severe
Database

Clinical effect not specified

Source: DDInter

Acalabrutinib
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Adalimumab
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Alteplase
Severe
Database

Clinical effect not specified

Source: DDInter

Anagrelide
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Antithrombin Alfa
Severe
Database

Clinical effect not specified

Source: DDInter

Antithrombin Iii Human
Severe
Database

Clinical effect not specified

Source: DDInter

Apixaban
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Argatroban
Severe
Database

Clinical effect not specified

Source: DDInter

Aspirin
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Avapritinib
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Baricitinib
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Ask House about tositumomab

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Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team