Adalimumab
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Drug reference
trifluridine
Fluorinated pyrimidine nucleoside · Antiviral (Antiherpesvirus)
Fluorinated pyrimidine nucleosideAntiviral (Antiherpesvirus)
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
- AdalimumabSevereDatabaseDDInter
- BaricitinibSevereDatabaseDDInter
- CertolizumabSevereDatabaseDDInter
- CladribineSevereDatabaseDDInter
Mechanism
Trifluridine is a fluorinated pyrimidine nucleoside that inhibits replication of herpesviruses, including acyclovir-resistant strains, and also inhibits cellular DNA synthesis at relatively low concentrations. Trifluridine monophosphate irreversibly inhibits thymidylate synthase, and trifluridine triphosphate is a competitive inhibitor of thymidine triphosphate incorporation into DNA. Trifluridine is incorporated into viral and cellular DNA.
Indications
primary keratoconjunctivitis due to HSV types 1 and 2recurrent epithelial keratitis due to HSV types 1 and 2acyclovir-resistant HSV cutaneous infections (topical)herpes simplex virus (eye drops)metastatic colorectal cancers (in fixed combination with tipiracil, for patients who have previously received other standard combination treatments including FOLFIRINOX)herpes simplex keratitis and keratoconjunctivitisH. simplex keratitisocular orthopoxviral infections (treatment)ocular prophylaxis for periorbital lesions
Dosing
- Adult
- Instillation of one drop into the affected eye(s) every 2 h while awake for the first 2 weeks and then four times daily for an additional 2 weeks.
Side effects
Common
discomfort on instillationpalpebral edemapunctate keratopathyhypersensitivityocular irritationlid edema
Drug interactions
Baricitinib
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Certolizumab
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Cladribine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Clozapine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Deferiprone
Severe
Database
Clinical effect not specified
Source: DDInter
Etanercept
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Fingolimod
Severe
Database
Clinical effect not specified
Source: DDInter
Golimumab
Severe
Database
Clinical effect not specified
Source: DDInter
Infliximab
Severe
Database
Clinical effect not specified
Source: DDInter
Leflunomide
Severe
Database
Clinical effect not specified
Source: DDInter
Measles Virus Vaccine Live Attenuated
Severe
Database
Clinical effect not specified
Source: DDInter
Related guidelines
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ESC · Cardiology · 2026
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IDSA · Infectious Diseases · 2010
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MOHFW · Gastroenterology · 2021
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ASH · Haematology · 2018
Hepatitis B — chronic infection
EASL · Gastroenterology · 2025
Ask House about trifluridine
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e, Goodman & Gilman 14e, Harrison 22e·Verified: 2026-05-10 · House clinical team