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trimipramine

Tricyclic Antidepressant (tertiary amine) · Antidepressant, Analgesic

Tricyclic Antidepressant (tertiary amine)Antidepressant, Analgesic
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
  • AmiodaroneSevereDatabaseDDInter
  • AmisulprideSevereDatabaseDDInter
  • AnagrelideSevereDatabaseDDInter
  • ArbutamineSevereDatabaseDDInter

Mechanism

Trimipramine antagonizes the serotonin transporter (SERT) and norepinephrine transporter (NET). It also blocks histamine H1, 5HT2, alpha-1 adrenergic, and muscarinic cholinergic receptors, contributing to its clinical effects and side effects.

Indications

depressionpsychotic depression (with first-generation antipsychotics)pain conditions

Pharmacokinetics

Half-life
16 hours (parent), 30 hours (active metabolite)
Metabolism
hepatic (CYP2D6, CYP2C19, CYP3A3/4, CYP1A2)

Side effects

Common
sedationcognitive dullingblurred visiondry mouthtachycardiaconstipationdifficulty urinatingorthostatic hypotensionweight gain
Serious
  • quinidine-like effects on cardiac conduction (life threatening in overdose)
  • lowered seizure threshold
  • serotonin syndrome (with MAOIs)

Drug interactions

Amiodarone
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Amisulpride
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Anagrelide
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Arbutamine
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Arsenic Trioxide
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Bedaquiline
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Bepridil
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Bupropion
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Buspirone
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Cabozantinib
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Ceritinib
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Chloroquine
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Related guidelines

Depression in adults
IPS · Psychiatry · 2023
Depression in adults
NICE · Psychiatry · 2022
Gastric premalignant conditions
ACG · Gastroenterology · 2025
Alcohol use disorder
MOHFW · Psychiatry · 2021
Schizophrenia
IPS · Psychiatry · 2017

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Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team