Drug reference

troglitazone

Antidiabetic

CDSCO approved

EXCRETION

—

not curated

INTERACTIONS

8 major

SEVERE in our sources

PREGNANCY

—

not curated

Top interactionssee all 8 →

GatifloxacinSevereDatabaseDDInter
LeflunomideSevereDatabaseDDInter
LomitapideSevereDatabaseDDInter
LumateperoneSevereDatabaseDDInter

Mechanism

Troglitazone activates the pregnane X receptor (PXR).

Drug interactions

Gatifloxacin

Severe

Database

Clinical effect not specified

Source: DDInter

Leflunomide

Severe

Database

Clinical effect not specified

Source: DDInter

Lomitapide

Severe

Database

Clinical effect not specified

Source: DDInter

Lumateperone

Severe

Database

Clinical effect not specified

Source: DDInter

Mipomersen

Severe

Database

Clinical effect not specified

Source: DDInter

Pexidartinib

Severe

Database

Clinical effect not specified

Source: DDInter

Ranolazine

Severe

Database

Clinical effect not specified

Source: DDInter

Teriflunomide

Severe

Database

Clinical effect not specified

Source: DDInter

4 additional low-confidence interactions hidden — those rows lack a documented mechanism or management plan in our sources.

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Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team