Drug reference

vaccinia virus vaccine

live attenuated Orthopoxvirus vaccine · vaccine

live attenuated Orthopoxvirus vaccinevaccine

CDSCO approved

EXCRETION

—

not curated

INTERACTIONS

—

none in our sources

PREGNANCY

—

not curated

Mechanism

Vaccinia virus vaccine is a live attenuated Orthopoxvirus vaccine, developed through multiple passages in cell culture to reduce virulence while retaining immunogenicity, providing protection against smallpox.

Indications

prevention of smallpoxnon-emergency use for laboratory and healthcare workers exposed occupationally to vaccinia virus, recombinant vaccinia viruses, or other orthopoxviruses (monkeypox, cowpox virus)

Related guidelines

Stroke and TIA — secondary prevention

AHA · Neurology · 2021

Tobacco-related cancer prevention

ICMR · Oncology · 2021

Cardiovascular disease prevention

ESC · Cardiology · 2021

Primary prevention of cardiovascular disease

AHA · Cardiology · 2019

Infective endocarditis prevention

ADA_DENTAL · Dentistry · 2015

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Textbook-sourced·Sources: Goodman & Gilman 14e·Updated: 2026-05-10