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vilazodone

SSRI, 5HT1A Receptor Partial Agonist · Antidepressant

SSRI, 5HT1A Receptor Partial AgonistAntidepressant
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
  • AlfentanilSevereDatabaseDDInter
  • AlmotriptanSevereDatabaseDDInter
  • AmitriptylineSevereDatabaseDDInter
  • AmoxapineSevereDatabaseDDInter

Mechanism

Functions as an SSRI and a partial agonist at the 5HT1A receptor, leading to a faster time of therapeutic onset than traditional SSRIs.

Side effects

Common
Sexual dysfunction
Serious
  • Serotonin syndrome

Drug interactions

Alfentanil
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Almotriptan
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Amitriptyline
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Amoxapine
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Amphetamine
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Amprenavir
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Atazanavir
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Benzphetamine
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Boceprevir
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Bupropion
Severe
Database

Drug interaction classified as: synergy.

Source: DDInter

Buspirone
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Ceritinib
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Related guidelines

Depression in adults
IPS · Psychiatry · 2023

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Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team