Drug reference

Adefovir dipivoxil

Antiviral · Antiviral for Hepatitis B

Also known as Bis-pom-PMEA

AntiviralAntiviral for Hepatitis B

CDSCO approvedSchedule H

EXCRETION

—

not curated

INTERACTIONS

—

none in our sources

PREGNANCY

(see Useful

FDA category + note

Mechanism

Adefovir dipivoxil is an oral nucleoside/nucleotide analog indicated for chronic hepatitis B virus (HBV) infection. Upon intracellular activation, its active metabolite interferes with the viral DNA synthesis pathway. This primarily involves inhibiting HBV DNA polymerase, leading to the suppression of viral replication and a reduction in HBV DNA levels.

Indications

Chronic hepatitis BLamivudine-resistant chronic hepatitis BChronic hepatitis B in patients co-infected with HIV who only require treatment for chronic hepatitis B (using antivirals not active against HIV)Chronic hepatitis B in patients with decompensated liver disease (in combination with lamivudine)chronic hepatitis B (including lamivudine-resistant cases and those with concurrent HIV infection)

Dosing

Adult: is given by mouth for the treatment of chronic hepatitis C infection, in double therapy with peginterferon alfa, interferon alfa, or sofosbuvir, or in triple therapy with peginterferon alfa and one protease inhibitor or sofosbuvir. Ribavirin is also effective in Lassa fever [unlicensed indication].…