Aspirin
Contraindicated
Textbook-cited
Increased risk of gastric bleeding
Concurrent use is contraindicated
Source: KDT 7e · p950
Drug reference
alcohol
Drug monograph
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
incl. contraindicated
PREGNANCY
—
not curated
Top interactionssee all 12 →
- AspirinContraindicatedTextbook-citedKDT 7e · p950
- CelecoxibContraindicatedTextbook-citedKDT 7e · p950
- DiclofenacContraindicatedTextbook-citedKDT 7e · p950
- IbuprofenContraindicatedTextbook-citedKDT 7e · p950
Mechanism
Not yet extracted
Indications
Prevention of bedsores (denatured spirit)After-shaveMinor cutsVehicle for liniments
Pharmacokinetics
Protein binding
Alcohol is eliminated by zero order kinetics, meaning a constant amount is eliminated in unit time, irrespective of concentration. Chronic alcoholism induces CYP2E1.
Metabolism
Alcohol is oxidized by CYP2E1 and dehydrogenase.
Contraindications
- Application on formed sores (irritating to raw surfaces)
Drug interactions
Celecoxib
Contraindicated
Textbook-cited
Increased risk of gastric bleeding
Concurrent use is contraindicated
Source: KDT 7e · p950
Diclofenac
Contraindicated
Textbook-cited
Increased risk of gastric bleeding
Concurrent use is contraindicated
Source: KDT 7e · p950
Ibuprofen
Contraindicated
Textbook-cited
Increased risk of gastric bleeding
Concurrent use is contraindicated
Source: KDT 7e · p950
Indomethacin
Contraindicated
Textbook-cited
Increased risk of gastric bleeding
Concurrent use is contraindicated
Source: KDT 7e · p950
Ketorolac
Contraindicated
Textbook-cited
Increased risk of gastric bleeding
Concurrent use is contraindicated
Source: KDT 7e · p950
Mefenamic Acid
Contraindicated
Textbook-cited
Increased risk of gastric bleeding
Concurrent use is contraindicated
Source: KDT 7e · p950
Naproxen
Contraindicated
Textbook-cited
Increased risk of gastric bleeding
Concurrent use is contraindicated
Source: KDT 7e · p950
Piroxicam
Contraindicated
Textbook-cited
Increased risk of gastric bleeding
Concurrent use is contraindicated
Source: KDT 7e · p950
Metronidazole
Contraindicated
Database
Disulfiram-like reaction: metronidazole inhibits aldehyde dehydrogenase (ALDH), causing accumulation of acetaldehyde. Severe nausea, vomiting, flushing, abdominal cramps, headache, hypotension.
Absolute alcohol avoidance during therapy and for at least 3 days after last dose. This includes alcohol-containing medications, mouthwashes, and cough syrups. Patient counseling mandatory.
Source: Kimi deep-research + Cla · p948
Dextropropoxyphene
Contraindicated
Database
Additive CNS/respiratory depression
Avoid; major contributor to historical deaths
Source: Kimi deep-research + Cla
Cefoperazone
Severe
Textbook-cited
Disulfiram-like reaction: flushing, nausea, vomiting, headache, palpitations
Warn patient to completely avoid alcohol during and 48h after treatment
Source: KDT 7e · p948
Related guidelines
Other Unclassified drugs
Ask House about alcohol
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e·Verified: 2026-05-10 · House clinical team